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Recent Publications

2018

Physical and chemical quality characteristics and antioxidant properties in strawberry cultivars (Fragaria x ananassa Duch.) in Greece: assessment of their sensory impact.

Zeliou K.; Papasotiropoulos V.,Manousopoulos Y.; Lamari F.N., 2018. Journal of the Science of the Food and Agriculture Aug; 98(11): 4065-4073.

αCGRP, another amyloidogenic member of the CGRP family.

Tsiolaki PL, Nasi GI, Baltoumas FA, Louros NN, Magafa V, Hamodrakas SJ, Iconomidou VA. 2018 J Struct Biol. pii: S1047-8477(18)30062-5.

Phytochemical and genetic characterization of styles of wild Crocus species from the island of Crete, Greece and comparison to those of cultivated C. sativus.

Lamari FN, Papasotiropoulos V, Tsiris D, Bariamis SE, Sotirakis K, Pitsi E, Vogiatzoglou AP, Iatrou G.  2018. Fitoterapia. 2018 Oct; 130: 225-233.

2017

Effect of acidic and enzymatic pretreatment on the analysis of mountain tea (Sideritis spp.) volatiles via distillation and ultrasound-assisted extraction.

Dimaki V., IatrouG., Lamari F. N., 2017. Journal of Chromatography A, 1524: 290–297

Optimized and Validated HPLC Analysis of St. John's Wort Extract and Final Products by Simultaneous Determination of Major Ingredients.

Zeliou K., Kontaxis N.I., Margianni E., Petrou C., and Lamari F.N., 2017. Journal of Chromatographic Science 55(8):805-812.

Saffron (Crocus sativus L.) Tea Intake Prevents Learning/Memory Defects and Neurobiochemical Alterations Induced by Aflatoxin B1 Exposure in Adult Mice

Linardaki Z., Lamari F.N., Margarity M., 2017. Neurochem. Res. 42(10): 2743-2754

Molecular requirements involving the human platelet protease-activated receptor-4 mechanism of activation by peptide analogues of its tethered-ligand.

Moschonas IC, Kellici TF, Mavromoustakos T, Stathopoulos P, Tsikaris V, Magafa V, Tzakos AG, Tselepis AD. Platelets. 2017 Dec;28(8):812-821.

2016

Structure–activity relationship study of angiotensin II analogs in terms of b-arrestin-dependent signaling to aldosterone production.

Τh. R. Valero, E. Sturchler, M. Jafferjee, G. Rengo, V. Magafa, P. Cordopatis+, P. McDonald, W. J. Koch, A. Lymperopoulos. Pharmacology Research & Perspectives (2016), 4 (2), DOI: 10.1002/prp2.226

Exploring new scaffolds for Angiotensin II receptor antagonism

P. Zoumpoulakis, E. Kritsi, M. T Matsoukas, C. Potamitis, Vl. Karageorgos, A. Athanasakis, A. Detsi, V. Magafa, G. Liapakis, Th. Mavromoustakos. Bioorganic & Medicinal Chemistry (2016), 24(18), 4444-4451

Quercetin glycosides and chlorogenic acid in highbush blueberry leaf decoction prevent cataractogenesis in vivo and in vitro: Investigation of the effect on calpains, antioxidant and metal chelating properties.

Ferlemi AV, Makri OE, Mermigki PG, Lamari FN, Georgakopoulos CD.

Exp Eye Res. 2016 Apr;145:258-68. doi: 10.1016/j.exer.2016.01.012.

Berry Leaves: An Alternative Source of Bioactive Natural Products of Nutritional and Medicinal Value.

Ferlemi AV, Lamari FN.

Antioxidants (Basel). 2016 Jun 1;5(2). pii: E17. doi: 10.3390/antiox5020017. Review.

2015

Validated capillary electrophoretic assays for disaccharide composition analysis of galactosaminoglycans in biologic samples and drugs/nutraceuticals.

Asimakopoulou AP, Malavaki C, Afratis NA, Theocharis AD, Lamari FN, Karamanos NK. Methods Mol Biol. 2015;1229:129-41. doi: 10.1007/978-1-4939-1714-3_13.

Cerebral Area Differential Redox Response of Neonatal Rats to Selenite-Induced Oxidative Stress and to Concurrent Administration of Highbush Blueberry Leaf Polyphenols.

Ferlemi AV, Mermigki PG, Makri OE, Anagnostopoulos D, Koulakiotis NS, Margarity M, Tsarbopoulos A, Georgakopoulos CD, Lamari FN. Neurochem Res. 2015 Nov;40(11):2280-92. doi: 10.1007/s11064-015-1718-7.

Cerebral Area Differential Redox Response of Neonatal Rats to Selenite-Induced Oxidative Stress and to Concurrent Administration of Highbush Blueberry Leaf Polyphenols.

Ferlemi AV, Mermigki PG, Makri OE, Anagnostopoulos D, Koulakiotis NS, Margarity M, Tsarbopoulos A, Georgakopoulos CD, Lamari FN. Neurochem Res. 2015 Nov;40(11):2280-92. doi: 10.1007/s11064-015-1718-7.

 
Quantitation of Crocins and Picrocrocin in Saffron by HPLC: Application to Quality Control and Phytochemical Differentiation from Other Crocus Taxa.

Koulakiotis NS, Gikas E, Iatrou G, Lamari FN, Tsarbopoulos A. Planta Med. 2015 May;81(7):606-12. doi: 10.1055/s-0035-1545873.

Rosemary tea consumption results to anxiolytic- and anti-depressant-like behavior of adult male mice and inhibits all cerebral area and liver cholinesterase activity; phytochemical investigation and in silico studies.

Ferlemi AV, Katsikoudi A, Kontogianni VG, Kellici TF, Iatrou G, Lamari FN, Tzakos AG, Margarity M. Chem Biol Interact. 2015 Jul 25;237:47-57. doi: 10.1016/j.cbi.2015.04.013.

Validated capillary electrophoretic assays for disaccharide composition analysis of galactosaminoglycans in biologic samples and drugs/nutraceuticals.

Asimakopoulou AP, Malavaki C, Afratis NA, Theocharis AD, Lamari FN, Karamanos NK. Methods Mol Biol. 2015;1229:129-41. doi: 10.1007/978-1-4939-1714-3_13.

Structural studies and cytotoxicity assays of "aggregation-prone" IAPP8-16 and its non-amyloidogenic variants suggest its important role in fibrillogenesis and cytotoxicity of human amylin.

Louros NN, Tsiolaki PL, Zompra AA, Pappa EV, Magafa V, Pairas G, Cordopatis P, Cheimonidou C, Trougakos IP, Iconomidou VA, Hamodrakas SJ. Biopolymers. 2015 May;104(3):196-205. doi: 10.1002/bip.22650.

Involvement of angiotensin II type 2 receptor (AT2R) signaling in human pancreatic ductal adenocarcinoma (PDAC): a novel AT2R agonist effectively attenuates growth of PDAC grafts in mice.

Ishiguro S, Yoshimura K, Tsunedomi R, Oka M, Takao S, Inui M, Kawabata A, Wall T, Magafa V, Cordopatis P, Tzakos AG, Tamura M. Cancer Biol Ther. 2015;16(2):307-16. doi: 10.1080/15384047.2014.1002357.

2014

Structural studies of "aggregation-prone" peptide-analogues of teleostean egg chorion ZPB proteins.

Louros NN, Petronikolou N, Karamanos T, Cordopatis P, Iconomidou VA, Hamodrakas SJ. Biopolymers. 2014 Nov;102(6):427-36. doi: 10.1002/bip.22563.

The Thyroxine-Containing Thyroglobulin Peptide (aa 2549-2560) Is a Target Epitope in Iodide-Accelerated Spontaneous Autoimmune Thyroiditis.

P. Kolypetri, K. Carayanniotis, S. Rahman , PE. Georghiou, V. Magafa, P. Cordopatis, G. Carayanniotis . Journal of Immunology (2014), pii: 1400561.

Electronic Sculpting of Ligand-GPCR Subtype Selectivity: The Case of Angiotensin II.

F. Magnani, CG. Pappas, T. Crook, V. Magafa, P.Cordopatis, S. Ishiguro, N. Ohta, J. Selent, S. Bosnyak, ES. Jones, IP. Gerothanassis, M. Tamura, RE. Widdop, AG. Tzakos . ACS Chem Biol. DOI: 10.1021/cb500063y

[DOTA]Somatostatin-14 analogs and their (111)In-radioligands: effects of decreasing ring-size on sst1-5 profile, stability and tumor targeting.

A.Tatsi, T. Maina, R. Cescato, B. Waser, EP. Krenning, M. de Jong, P. Cordopatis, JC. Reubi, BA. Nock . European Journal of Medicinal Chemistry, 73, 3 (2014)

Zn(II)/pyridyloxime complexes as potential reactivators of OP-inhibited acetylcholinesterase: in vitro and docking simulation studies.

KF. Konidaris, GA. Dalkas, E. Katsoulakou, G. Pairas, CP. Raptopoulou, F.N. Lamari, GA Spyroulias, E. Manessi-Zoupa. Journal of Inorganic Biochemistry, 134, 12 (2014)

2013

Simultaneous determination of allantoin and glycolic acid in snail mucus and cosmetic creams with high performance liquid chromatography and ultraviolet detection.

MA. El Mubarak, FN. Lamari, C. Kontoyannis. Journal of Chromatography A, 1322, 49 (2013)

Olive leaf extracts are a natural source of advanced glycation end product inhibitors.

VG. Kontogianni, P. Charisiadis, E. Margianni, FN. Lamari, IP. Gerothanassis, AG. Tzakos. Journal of Medicinal Food, 16(9), 817 (2013)

Saffron administration prevents selenite-induced cataractogenesis.

OE. Makri, AV. Ferlemi, FN. Lamari, CD. Georgakopoulos. Molecular Vision, 19, 1188 (2013)

Phytochemical composition of "mountain tea" from Sideritis clandestina subsp. clandestina and evaluation of its behavioral and oxidant/antioxidant effects on adult mice.

CG. Vasilopoulou, VG. Kontogianni, ZI. Linardaki, G. Iatrou, FN. Lamari, AA. Nerantzaki, IP. Gerothanassis, AG. Tzakos, M. Margarity. European Journal of Nutrition, 52(1), 107 (2013)

Investigation of the neuroprotective action of saffron (Crocus sativus L.) in aluminum-exposed adult mice through behavioral and neurobiochemical assessment.

ZI. Linardaki, MG. Orkoula, AG. Kokkosis, FN. Lamari, M. Margarity. Food and Chemical Toxicology, 52, 163 (2013)

Protective mechanisms against oxidative stress and angiopathy in young patients with diabetes type 1 (DM1).

N. Koutroumani, I. Partsalaki, F. Lamari, A. Dettoraki, AP. Gil, A. Karvela, E. Kostopoulou, BE. Spiliotis. Journal of Pediatric Endocrinology and Metabolism, 26(3-4), 309 (2013)

In Search of a "Natural" Treatment of Cataract

AV. Ferlemi, OE. Makri, CD. Georgakopoulos, FN. Lamari Medicinal and Aromatic Plants, 2(2), 1 (2013)

2012

Clinical Outcome of Patients with Various Advanced Cancer Types Vaccinated with an Optimized Cryptic Human Telomerase Reverse Transcriptase (TERT) Peptide: Results of an Expanded Phase II Study

A. Kotsakis, E-K. Vetsika, S. Christou, D. Hatzidaki, N. Vardakis, D. Aggouraki, G. Konsolakis, V. Georgoulias, Ch. Christophyllakis, P. Cordopatis, K. Kosmatopoulos and D. Mavroudis. Annals of Oncology, 23, 442 (2012)

Pleiotrophin Expression and Role in Physiological Angiogenesis in vivo: Potential Involvement of Nucleolin

M. Koutsioumpa, G. Drosou, C. Mikelis, K. Theochari, D. Vourtsis, P. Katsoris, E. Giannopoulou, J. Courty, C. Petrou, V. Magafa, P. Cordopatis and E. Papadimitriou. Vascular Cell, 4, 4 (2012)

[111In-DOTA] Somatostatin-14 Analogs as Potential Pansomatostatin-Like Radiotracers-First Results of a Preclinical Study

A. Tatsi, T. Maina, R. Cescato, B. Waser, E. Krenning, M. de Jong, P. Cordopatis, J.-C. Reubi and B. Nock. European Journal of Nuclear Medicine and Molecular Imagine, Research, 2, 25 (2012).

Structure Activity Studies of lGnRH-III Through Rational Amino Acid Substitution and NMR Conformational Studies

E. Pappa, A. Zompra, Z. Diamantopoulou, Z. Spyranti, G. Pairas, F. Lamari, P. Katsoris, G. Spyroulias and P. Cordopatis. Biopolymers: Peptide Science, in press.

Saffron as a source of novel acetylcholinesterase inhibitors: molecular docking and in vitro enzymatic studies

G.D. Geromichalos, F.N. Lamari, M.A. Papandreou, D.T. Trafalis, M. Margarity, A. Papageorgiou, Z. Sinakos. J. Agric. Food Chem. 60(24), 6131 (2012)

Wild Blueberry (V. angustifolium)-Enriched Diets Alter Aortic Glycosaminoglycan Profile in the Spontaneously Hypertensive Rat

A. Kristo, C. Malavaki, F. Lamari, N. Karamanos, D. Klimis-Zacas. J. Nutr. Biochem. 23(8), 961 (2012)

Cell-Line Specific Protection by Berry Polyphenols Against Hydrogen Peroxide Challenge and Lack of Effect on Metabolism of Amyloid Precursor Protein.

M. Papandreou, M. Tsachaki, S. Efthimiopoulos, D. Klimis-Zacas, M. Margarity and F. Lamari. Phytother Res. 26(7), 956 (2012)

2011

Phytochemical Composition of “Mountain tea” from Sideritis clandestina subsp clandestina and Evaluation of its Behavioral and Oxidant/Antioxidant Effects on Adult Mice

C. Vasilopoulou, V. Kontogianni, Z. Linardaki, G. Iatrou, F. Lamari, A. Nerantzaki, I. Gerothanassis, A. Tzakos, M. Margarity. Eur J Nutr. 2011 Dec 28. [Epub ahead of print].

Insights into Ectopic Estrogen Receptor Expression Nucleocytoplasmic Distribution and Interaction with Chromatin Obtained with new Antibodies to Estrogen Receptors α and β

N. Chantzi, A. Meligova, E. Dhimolea, C. Petrou, D. Mitsiou, V. Magafa, A. Pechtelidou, I. Forentin, E. Kitriki, P. Cordopatis, D. Tiniakos, M. Alexis. Steroids, 76, 974 (2011).

Heparan sulfate: biological significance, tools for biochemical analysis and structural characterization.

C. Malavaki, A. Theocharis, F. Lamari, I. Kanakis, T. Tsegenidis, G. Tzanakakis, N. Karamanos. Biomed Chromatogr. 2011; 25(1-2):11-20.

The Silkmoth Eggshell as a Natural Amyloid Shield for the Safe Development of Insect Oocyte and Embryo: Insights from Studies of Silkmoth Chorion Protein Peptide-Analogues of the B Family.

V. Iconomidou, P. Cordopatis, A. Hoenger and S. Hamodrakas. Biopolymers: Peptide Science, (2011); 96:273.

Enzymatic Stability, Solution Structure, and Antiproliferative Effect on Prostate Cancer Cells of Leuprolide and New GnRH Peptide Analogs.

E.V Pappa, A. Zompra, Z. Spyranti, Z. Diamantopoulou, G. Pairas, F.N. Lamari, P. Katsoris, G.A. Spyroulias and P. Cordopatis. Biopolymers: Peptide Science, (2011); 96: 260.

Xanthones in Heterocyclic Synthesis. An Efficient and General Route for the Synthesis of Regioselectively Substituted Phthalazines.

Y. Gardikis, P. Tsoungas, C. Potamitis, G. Pairas, M. Zervou and P. Cordopatis. Heterocycles, (2011); 89: 1291.

Xanthone in Heterocyclic Synthesis. An Efficient Route for the Synthesis of C-3 o-Hydroxyaryl Substituted 1,2-Benzisoxazoles and their N-Oxides. Potential Scaffold for Angiotensin (II) Antagonist Hybrid Peptides.

Y. Gardikis, P. Tsoungas, C. Potamitis, M. Zervou and P. Cordopatis. Heterocycles, (2011); 83: 1077.

A Peptide Corresponding to the C-Terminal Region of Pleiotrophin Inhibits Angiogenesis in vivo and in vitro.

C. Mikelis, M. Lamprou, M. Koutsioumpa, A. Koutsioubas, Z. Spyranti, A. Zompra, N. Spiliopoulos, A. Vradis, P. Katsoris, G. Spyroulias, P. Cordopatis, J. Courty and E. Papadimitriou. Journal of Cellular Biochemistry, (2011); 112: 1532.

Memory Enhancing Effects of Saffron in Aged Mice are Correlated with Antioxidant Protection.

M. Papandreou, M. Tsachaki, S. Efthimiopoulos, P. Cordopatis. F. Lamari and M. Margarity. Behavioural Brain Research, (2011); 219: 197.

A new Validated SPE-HPLC Method for Monitoring Crocetin in Human Plasma-Application After Saffron Tea Consumption.

D. Chryssanthi, F. Lamari, C. Georgakopoulos and P. Cordopatis. Journal of Pharmaceutical and Biomedical Analysis, (2011); 55: 563.

Crocetin Inhibits Invasiveness of ΜDA-MB-231 Breast Cancer Cells via Downregulation of Matrix Metalloproteinases.

D. Chryssanthi, P. Dedes, N. Karamanos, P.Cordopatis and F. Lamari. Planta Medica, (2011); 77: 146.

Differential Antioxidant Effects of Consuming Tea From Sideritis clandestina subsp. peloponnesiaca on Cerebral Regions of Adult Mice.

Z. Linardaki, C. Vasilopoulou, C. Constantinou, G. Iatrou, F. Lamari, M. Margarity. Journal of Medicinal Food, (2011); 14(9):1060.